Polynucleotides – Regenerative Skin Rejuvenation & Deep Repair
Polynucleotides (PN) are highly purified molecules derived from DNA fragments that activate cell regeneration, improve skin quality, and restore dermal structure. Injected into the skin, they promote fibroblast activity, boost collagen synthesis, reduce inflammation, and help repair damaged or ageing tissue — making them a powerful solution for deep skin restoration.
Ideal for those with sensitive, ageing, or compromised skin, polynucleotide treatments deliver long-term improvement in texture, hydration, and elasticity without adding volume.
What to Expect:
- Duration: 30–45 minutes
- Pain Level: Mild (topical numbing available)
- Downtime: Possible redness, swelling or pinpoint bruising for 1–2 days
- Sessions Recommended: 3–4 sessions, spaced 2–3 weeks apart
- Visible Results: Improved hydration and glow after 1–2 sessions; stronger structural changes over time
- Effect Duration: 6–9 months with maintenance
Ideal For:
- Sensitive or reactive skin
- Early signs of ageing and dullness
- Thin, crepey or atrophic skin
- Post-acne or skin barrier repair
- Under-eye area (dark circles, crepiness)
Additional Benefits
- Stimulates collagen and elastin production
- Improves skin hydration and elasticity
- Smooths fine lines and wrinkles
- Reduces redness and inflammation
- Brightens dull, tired-looking skin
- Aids recovery after laser, microneedling or peel treatments
- Safe and effective for delicate areas including under-eyes and neck
- Long-lasting results (up to 12 months)
Real Results
After
Before
Your Safety, Our Priority
All polynucleotide treatments at La Rose Clinic are performed by qualified aesthetic practitioners in our CQC-registered medical facility. We use only high-purity, clinically approved polynucleotide products and adhere to the latest evidence-based safety standards.
Procedure
- Consultation – Skin is assessed and treatment plan created
- Cleansing – Skin is cleansed and disinfected
- Numbing – Anaesthetic cream applied (15–20 min)
- Injections – Polynucleotides injected with fine needles
- Soothing – Calming cream or mask applied
- Aftercare – Instructions provided for home care
Aftercare
Our La Rose Clinic specialists recommend:
Keep skin clean and hydrated with gentle moisturisers
Use SPF 30+ daily to protect healing skin
Apply cold compresses if swelling or redness occurs (first 24 hrs)
Drink plenty of water to support skin regeneration
Avoid (First 24–72 Hours):
No makeup for at least 24 hours
Avoid heat exposure (sun, saunas, hot showers, steam rooms)
No vigorous exercise for 24 hours
Do not touch, rub, or massage the treated areas
Avoid active skincare (retinol, acids, scrubs) for 5–7 days
Need help choosing ?
We offer comprehensive consultations to help you understand your skin, body, and wellness needs. Whether you have a specific concern or simply want expert advice, our clinicians are here to guide you without pressure.
Polynucleotide Injections FAQ: La Rose Clinic, Holborn, London
Polynucleotide injections, offered at La Rose Clinic in Holborn, London, are advanced bio-stimulatory treatments using purified DNA fragments, typically derived from salmon or trout. Unlike fillers, they stimulate skin regeneration at a cellular level, boosting collagen, elastin, and hydration for a radiant, youthful complexion. They’re ideal for natural skin rejuvenation.
When administered by La Rose Clinic’s medically trained professionals in our CQC-registered facility, polynucleotide injections are safe and use high-purity, MHRA-approved products. Mild, temporary side effects like redness or swelling may occur. Our team adheres to evidence-based safety standards for optimal care.
At La Rose Clinic, polynucleotides target the face, under-eyes, neck, décolletage, or hands to improve skin elasticity, hydration, and texture. They’re effective for fine lines, acne scars, and sensitive or acne-prone skin, customised to your needs during a consultation.
A polynucleotide session at La Rose Clinic typically takes 30-45 minutes, depending on the treatment area. With minimal downtime, it’s a convenient option for busy Londoners seeking regenerative skin solutions.
Initial results, like improved hydration, appear within 2-3 weeks, with optimal effects after 6-8 weeks as collagen production increases. At La Rose Clinic, results typically last 6-9 months, with maintenance sessions recommended for sustained benefits.
Most clients at La Rose Clinic experience mild discomfort, described as a slight sting. We use fine needles and may apply numbing cream to ensure a comfortable polynucleotide experience in our Holborn clinic.
Common side effects include temporary redness, swelling, or small bumps at the injection sites, resolving within 1-2 days. Bruising is rare but possible. La Rose Clinic’s expert team minimises risks for safe treatments.
Polynucleotides are not suitable for pregnant or breastfeeding women, those undergoing IVF, or individuals with seafood allergies (due to the salmon-derived product). Share your medical history during your La Rose Clinic consultation for safety.
Avoid alcohol, blood-thinning medications (e.g., ibuprofen), and supplements like fish oil for 48 hours before treatment to reduce bruising. Stay hydrated and discuss medications with our La Rose Clinic team beforehand.
Avoid touching or massaging the treated area, applying makeup, or exposing skin to heat (e.g., saunas) for 24-48 hours. Refrain from strenuous exercise for 24 hours to optimise results at La Rose Clinic.
At La Rose Clinic, polynucleotide pricing is transparent, starting at £350 per session or £950 for a course of three sessions (recommended for optimal results). Costs are discussed during your free consultation. Visit www.laroseclinic.co.uk for details.
Yes, at La Rose Clinic, polynucleotides are often paired with Botox, dermal fillers, or HydraFacial for enhanced rejuvenation. Our Holborn team creates bespoke plans to meet your aesthetic goals.
La Rose Clinic recommends a course of 2-4 sessions, spaced 2-4 weeks apart, for optimal results, with maintenance treatments every 6-9 months to sustain skin vitality for our London clients.
Polynucleotides at La Rose Clinic deliver natural-looking results by stimulating your skin’s own repair processes. Our skilled practitioners ensure a subtle, radiant glow that enhances your natural beauty.
La Rose Clinic, located in Holborn, is a CQC-registered, medically led aesthetic clinic. Our highly trained professionals use premium polynucleotide products for safe, effective results. Book a free consultation at www.laroseclinic.co.uk or call 020 3958 0470.
La Rose Clinic Difference
What makes us different from other clinics